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Eye Drops Recall: FDA Finds Contaminated Conditions At Manufacturer

The manufacturer of eye drops linked to antibiotic-resistant infections did not meet proper sanitary safety and quality assurance measures, according to a preliminary inspection report from the Food and Drug Administration (FDA).

The eye drops were recalled in February. Health inspectors found 11 problems at Global Pharma Healthcare's manufacturing site in Tamilnadu, India. Observations made during an 11-day inspection beginning in late February included:

  • "Black, brown colored greasy deposit" on a bowl used to transfer bottles
  • "Deficient" processing areas for cleaning and disinfecting the room
  • Floors, walls and ceilings were not "easily cleanable"
  • Container closures were "not cleaned, sanitized, decontaminated or sterilized"
  • A lack of written procedures for cleaning or maintaining equipment
  • The eye drops were sold in the U.S. Under the brands EzriCare Artificial Tears and Delsam Pharma's Artificial Tears. They caused 68 known bacterial infections, leading to three deaths, eight cases of vision loss and four individuals who required surgical removal of their eyeball because of the infection, the Centers for Disease Control and Prevention (CDC) said.  

    The type of infection linked to the drops, Pseudomonas aeruginosa, is resistant to antibiotics and poses a greater threat to those who are immunocompromised. CDC testing determined the bacteria in the recalled products was resistant to antibiotics such as carbapenem, ceftazidime and cefepime. 

    Although most infections were linked to the EzriCare brand of eye drops, patients with infections reported using more than 10 different brands of artificial tears.

    Though preservative-free drops are recommended for people who apply artificial tears more than four times a day or have moderate to severe dry eyes, they are more likely to support bacterial growth after the bottle is opened, according to the Mayo Clinic.

    According to the CDC, signs of an eye infection include:

  • Discharge from the eye
  • Pain or discomfort
  • Redness
  • Sensitivity to light
  • Blurry vision
  • A feeling like something is in the eye

  • Rarest Types Of Cancer

    Rare types of cancer, such as chronic myeloid leukemia and Ewing sarcoma, affect fewer than 15 people per 100,000 each year. Rare cancers can affect any part of the body and have different risk factors, symptoms, and outlooks.

    You may be familiar with some of the most common types of cancer. According to the American Cancer Society, these include lung cancer, breast cancer, prostate cancer, and colorectal cancer.

    However, some cancers are much rarer. The National Cancer Institute defines rare cancer as a cancer that affects fewer than 15 per 100,000 people each year.

    Many cancers are rare. In this article, we touch on just a few of the rarest types of cancer that you may or may not have heard of.

    Chronic myeloid leukemia (CML) is a slow growing type of leukemia that affects myeloid stem cells that eventually become blood cells like neutrophils.

    Even though it's one of the four main types of leukemia, CML is rare. In 2018, it was estimated to occur in 1 out of 100,000 people globally.

    The risk of CML increases with age, and it's also more common in males. Previous exposure to radiation is the only other known risk factor.

    Symptoms of CML can include:

  • weakness and fatigue
  • fever
  • night sweats
  • unintentional weight loss
  • bone pain
  • enlarged spleen, which can cause a feeling of fullness on your left side below your ribs
  • The overall 5-year survival rate for people with CML is 70.4%.

    Eye cancer is any type of cancer that begins in the eye. Ocular melanoma is the most common type of eye cancer in adults, but only affects 5 out of 1 million people in the United States. Other eye cancers are less common and include:

    The risks for eye cancer can depend on the specific type of cancer. For example, some risk factors for ocular melanoma include older age, a family history of melanoma, and having lighter colored skin or eyes.

    General symptoms of eye cancer can include things like:

    Survival rates for eye cancer can vary based on the type. The table below shows the 5-year relative survival rates for ocular melanoma, the most common eye cancer in adults.

    Gallbladder cancer starts in the gallbladder, which stores bile used for digestion. In the United States, it occurs in 1.4 out of 100,000 females and 0.8 out of 100,000 males.

    Some of the known risk factors for gallbladder cancer include:

  • older age
  • being female
  • a family history of gallbladder cancer
  • a history of gallstones
  • other gallbladder or bile duct conditions like:
  • obesity
  • The symptoms of gallbladder cancer can include:

    The table below shows the 5-year relative survival rates for gallbladder cancer.

    Hairy cell leukemia (HCL) is a type of slow growing leukemia that affects B cells, which are immune cells that make antibodies. In HCL, the affected cells appear "hairy" under a microscope.

    HCL is more common in men and is estimated to affect 0.3 out of 100,000 males and 0.1 out of 100,000 females globally. The risk of HCL increases with age.

    People with HCL typically have low blood counts, which can lead to anemia, an increased risk of infection, and easy bruising or bleeding. The spleen may also become enlarged, leading to abdominal swelling and pain.

    When it's treated, the 5-year event-free survival for HCL is about 90%. Some research has also found that people with HCL can have a typical life span with treatment.

    Hepatoblastoma is a type of liver cancer that mainly affects children. Despite being the most common type of liver cancer in this age group, it's still very rare. Hepatoblastoma affects 1.5 out of 1 million people each year.

    While many cases of hepatoblastoma happen randomly, about one-third are associated with inherited conditions like Beckwith-Weidemann syndrome and familial adenomatous polyposis. A low birth weight also increases risk.

    Symptoms of hepatoblastoma can include:

  • an abdominal lump that can be painful and continues to get larger
  • abdominal swelling
  • reduced appetite
  • unintentional weight loss
  • nausea and vomiting
  • Research has found that the overall 5-year survival for hepatoblastoma is 81.9%.

    Kaposi sarcoma (KS) starts in cells that line your blood vessels. It's caused by infection with a virus called Kaposi sarcoma-associated herpesvirus (KSHV). KS affects 6 out of 1 million people in the United States each year.

    Throughout the world, there are many more people with KSHV than with KS. This is because the main risk factor for KS is a weakened immune system, which can happen due to living with HIV, receiving an organ transplant, or the natural process of aging.

    The symptoms of KS can include:

  • skin lesions, which:
  • most often occur on the lower body and face, may be raised or flat, and are typically red, brown, or purple in color
  • can cause pain and swelling
  • mouth or throat lesions
  • lesions inside the body that may bleed or interfere with the functions of affected organs and tissues
  • The table below shows the 5-year relative survival rates for KS.

    While breast cancer most often affects the breasts of females, it can also occur in the breasts of males. In 2017, the Centers for Disease Control and Prevention (CDC) found that this rare type of breast cancer affected 1.28 out of 100,000 males.

    The factors that increase the risk of breast cancer in males include:

  • older age
  • a family history of breast cancer, especially if other fathers or brothers in the family have had it
  • certain gene mutations, like those in BRCA1 and BRCA2
  • previous radiation exposure
  • high estrogen levels
  • Klinefelter syndrome
  • The main symptom of breast cancer in males is a lump or bump in your breast that you can feel and that's typically painless. Other symptoms can include:

  • changes to the skin of your breast, such as redness or dimpling
  • changes in the size or shape of your breast
  • pain or discharge from your nipple
  • a nipple that turns inward
  • The table below shows the 5-year relative survival rates.

    Retinoblastoma is a type of cancer that affects the retina of the eye in children. It's the most common eye cancer in children, affecting 11 out of 1 million children younger than age 5 worldwide.

    Retinoblastoma is caused by having a gene change that can be inherited. Because of this, having a family history of retinoblastoma puts a child at a higher risk of having this type of cancer.

    The symptoms of retinoblastoma can include:

    More than 90% of children with retinoblastoma can go into remission (meaning that cancer isn't detectable and isn't expected to return) with treatment. In fact, research has found that the 5-year survival rate is 96.3% when retinoblastoma impacts one eye and is 92.5% when both eyes are affected.

    Vaginal cancer is cancer that starts in the vagina, which is the part of the female reproductive tract that connects the cervix to the outside of the body.

    The CDC estimates that 0.6 out of 100,000 women in the United States received a vaginal cancer diagnosis in 2019.

    The risk factors for vaginal cancer are:

  • older age
  • HPV infection
  • a history vaginal, vulvar, or cervical precancers
  • smoking
  • exposure to the drug diethylstilbestrol (DES)
  • HIV/AIDS
  • Some of the symptoms of vaginal cancer are:

    The table below shows the 5-year relative survival rates for vaginal cancer.

    There are many types of rare cancer. These cancers can occur in any part of the body and can vary in their associated risk factors, symptoms, and outlook.

    Generally speaking, the outlook for any cancer is best when it's diagnosed and treated early. It's recommended that you talk with a doctor if you develop concerning symptoms that are persistent or continue to get worse.


    Glaucoma And Dry Eye Diseases Market Share By 2031

    The MarketWatch News Department was not involved in the creation of this content.

    Mar 26, 2023 (The Expresswire) -- The "Glaucoma and Dry Eye Diseases Market" study describes how the technology industry is evolving and how major and emerging players in the industry are responding to long term opportunities and short-term challenges they face. One major attraction about Glaucoma and Dry Eye Diseases Industry is its growth rate. Many major technology players are [Aerie Pharmaceuticals, Inc., AbbVie, Bausch and Lomb Incorporated, Alcon, Merck and Co., Inc., Otsuka Pharmaceutical Co., Ltd., Novartis AG, Santen Pharmaceutical Co., Ltd., Viatris Inc., Akorn, Inc.] have been looking into Glaucoma and Dry Eye Diseases as a way to increase their market share and reach towards consumers.

    What is the Glaucoma and Dry Eye Diseases market growth?

    Glaucoma and Dry Eye Diseases Market Size is projected to Reach Multimillion USD by 2029, In comparison to 2023, at unexpected CAGR during the forecast Period 2023-2029.

    Browse Detailed TOC, Tables and Figures with Charts which is spread across 100 Pages that provides exclusive data, information, vital statistics, trends, and competitive landscape details in this niche sector.

    Client Focus

    1. Does this report consider the impact of COVID-19 and the Russia-Ukraine war on the Glaucoma and Dry Eye Diseases market?

    Yes. As the COVID-19 and the Russia-Ukraine war are profoundly affecting the global supply chain relationship and raw material price system, we have definitely taken them into consideration throughout the research, and in Chapters, we elaborate at full length on the impact of the pandemic and the war on the Glaucoma and Dry Eye Diseases Industry

    Final Report will add the analysis of the impact of Russia-Ukraine War and COVID-19 on this Glaucoma and Dry Eye Diseases Industry.

    TO KNOW HOW COVID-19 PANDEMIC AND RUSSIA UKRAINE WAR WILL IMPACT THIS MARKET - REQUEST SAMPLE

    This research report is the result of an extensive primary and secondary research effort into the Glaucoma and Dry Eye Diseases market. It provides a thorough overview of the market's current and future objectives, along with a competitive analysis of the industry, broken down by application, type and regional trends. It also provides a dashboard overview of the past and present performance of leading companies. A variety of methodologies and analyses are used in the research to ensure accurate and comprehensive information about the Glaucoma and Dry Eye Diseases Market.

    Which are the driving factors of the Glaucoma and Dry Eye Diseases market?

    Growing demand for [Hospital, Pharmacy Store, Online Sales] around the world has had a direct impact on the growth of the Glaucoma and Dry Eye Diseases

    The Glaucoma and Dry Eye Diseases segments and sub-section of the market are illuminated below:

    Based on Product Types the Market is categorized into [Glaucoma Drugs, Dry Eye Diseases Drugs] that held the largest Glaucoma and Dry Eye Diseases market share In 2022.

    Get a Sample PDF of report -https://www.360researchreports.Com/enquiry/request-sample/21366406

    Glaucoma and Dry Eye Diseases Market - Competitive and Segmentation Analysis:

    2.How do you determine the list of the key players included in the report?

    With the aim of clearly revealing the competitive situation of the industry, we concretely analyze not only the leading enterprises that have a voice on a global scale, but also the regional small and medium-sized companies that play key roles and have plenty of potential growth.

    Short Description About Glaucoma and Dry Eye Diseases Market:

    The Global Glaucoma and Dry Eye Diseases market is anticipated to rise at a considerable rate during the forecast period, between 2022 and 2029. In 2021, the market is growing at a steady rate and with the rising adoption of strategies by key players, the market is expected to rise over the projected horizon.

    The global Glaucoma and Dry Eye Diseases market size was valued at USD 12591.13 million in 2021 and is expected to expand at a CAGR of 3.84% during the forecast period, reaching USD 15782.74 million by 2027.

    The report combines extensive quantitative analysis and exhaustive qualitative analysis, ranges from a macro overview of the total market size, industry chain, and market dynamics to micro details of segment markets by type, application and region, and, as a result, provides a holistic view of, as well as a deep insight into the Glaucoma and Dry Eye Diseases market covering all its essential aspects.

    For the competitive landscape, the report also introduces players in the industry from the perspective of the market share, concentration ratio, etc., and describes the leading companies in detail, with which the readers can get a better idea of their competitors and acquire an in-depth understanding of the competitive situation. Further, mergers and acquisitions, emerging market trends, the impact of COVID-19, and regional conflicts will all be considered.

    In a nutshell, this report is a must-read for industry players, investors, researchers, consultants, business strategists, and all those who have any kind of stake or are planning to foray into the market in any manner.

    Get a Sample Copy of the Glaucoma and Dry Eye Diseases Report 2023

    3.What are your main data sources?

    Both Primary and Secondary data sources are being used while compiling the report.

    Primary sources include extensive interviews of key opinion leaders and industry experts (such as experienced front-line staff, directors, CEOs, and marketing executives), downstream distributors, as well as end-users. Secondary sources include the research of the annual and financial reports of the top companies, public files, new journals, etc. We also cooperate with some third-party databases.

    Geographically, the detailed analysis of consumption, revenue, market share and growth rate, historical data and forecast (2017-2027) of the following regions are covered in Chapters:

    ● North America (United States, Canada and Mexico) ● Europe (Germany, UK, France, Italy, Russia and Turkey etc.) ● Asia-Pacific (China, Japan, Korea, India, Australia, Indonesia, Thailand, Philippines, Malaysia and Vietnam) ● South America (Brazil, Argentina, Columbia etc.) ● Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)

    This Glaucoma and Dry Eye Diseases Market Research/Analysis Report Contains Answers to your following Questions

    ● What are the global trends in the Glaucoma and Dry Eye Diseases market? Would the market witness an increase or decline in the demand in the coming years? ● What is the estimated demand for different types of products in Glaucoma and Dry Eye Diseases? What are the upcoming industry applications and trends for Glaucoma and Dry Eye Diseases market? ● What Are Projections of Global Glaucoma and Dry Eye Diseases Industry Considering Capacity, Production and Production Value? What Will Be the Estimation of Cost and Profit? What Will Be Market Share, Supply and Consumption? What about Import and Export? ● Where will the strategic developments take the industry in the mid to long-term? ● What are the factors contributing to the final price of Glaucoma and Dry Eye Diseases? What are the raw materials used for Glaucoma and Dry Eye Diseases manufacturing? ● How big is the opportunity for the Glaucoma and Dry Eye Diseases market? How will the increasing adoption of Glaucoma and Dry Eye Diseases for mining impact the growth rate of the overall market? ● How much is the global Glaucoma and Dry Eye Diseases market worth? What was the value of the market In 2020? ● Who are the major players operating in the Glaucoma and Dry Eye Diseases market? Which companies are the front runners? ● Which are the recent industry trends that can be implemented to generate additional revenue streams? ● What Should Be Entry Strategies, Countermeasures to Economic Impact, and Marketing Channels for Glaucoma and Dry Eye Diseases Industry?

    Customization of the Report

    Can I modify the scope of the report and customize it to suit my requirements?

    Yes. Customized requirements of multi-dimensional, deep-level and high-quality can help our customers precisely grasp market opportunities, effortlessly confront market challenges, properly formulate market strategies and act promptly, thus to win them sufficient time and space for market competition.

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    Detailed TOC of Global Glaucoma and Dry Eye Diseases Market Insights and Forecast to 2029

    Major Points from Table of Contents

    Global Glaucoma and Dry Eye Diseases Market Research Report 2023-2029, by Manufacturers, Regions, Types and Applications

    1 Introduction1.1 Objective of the Study1.2 Definition of the Market1.3 Market Scope1.3.1 Market Segment by Type, Application and Marketing Channel1.3.2 Major Regions Covered (North America, Europe, Asia Pacific, Mid East and Africa)1.4 Years Considered for the Study (2015-2029)1.5 Currency Considered (U.S. Dollar)1.6 Stakeholders

    2 Key Findings of the Study

    3 Market Dynamics3.1 Driving Factors for this Market3.2 Factors Challenging the Market3.3 Opportunities of the Global Glaucoma and Dry Eye Diseases Market (Regions, Growing/Emerging Downstream Market Analysis)3.4 Technological and Market Developments in the Glaucoma and Dry Eye Diseases Market3.5 Industry News by Region3.6 Regulatory Scenario by Region/Country3.7 Market Investment Scenario Strategic Recommendations Analysis

    4 Value Chain of the Glaucoma and Dry Eye Diseases Market

    4.1 Value Chain Status4.2 Upstream Raw Material Analysis4.3 Midstream Major Company Analysis (by Manufacturing Base, by Product Type)4.4 Distributors/Traders4.5 Downstream Major Customer Analysis (by Region)

    5 Global Glaucoma and Dry Eye Diseases Market-Segmentation by Type6 Global Glaucoma and Dry Eye Diseases Market-Segmentation by Application

    7 Global Glaucoma and Dry Eye Diseases Market-Segmentation by Marketing Channel7.1 Traditional Marketing Channel (Offline)7.2 Online Channel

    8 Competitive Intelligence Company Profiles

    9 Global Glaucoma and Dry Eye Diseases Market-Segmentation by Geography

    9.1 North America9.2 Europe9.3 Asia-Pacific9.4 Latin America

    9.5 Middle East and Africa

    10 Future Forecast of the Global Glaucoma and Dry Eye Diseases Market from 2023-2029

    10.1 Future Forecast of the Global Glaucoma and Dry Eye Diseases Market from 2023-2029 Segment by Region10.2 Global Glaucoma and Dry Eye Diseases Production and Growth Rate Forecast by Type (2023-2029)10.3 Global Glaucoma and Dry Eye Diseases Consumption and Growth Rate Forecast by Application (2023-2029)

    11 Appendix11.1 Methodology12.2 Research Data Source

    Continued….

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    360 Research Reports is the credible source for gaining the market reports that will provide you with the lead your business needs. At 360 Research Reports, our objective is providing a platform for many top-notch market research firms worldwide to publish their research reports, as well as helping the decision makers in finding most suitable market research solutions under one roof. Our aim is to provide the best solution that matches the exact customer requirements. This drives us to provide you with custom or syndicated research reports.For More Related Reports Click Here :

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    To view the original version on The Express Wire visit Glaucoma and Dry Eye Diseases Market Share By 2031

    COMTEX_427583773/2598/2023-03-26T21:06:10

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