Otitis Media

Abstract OBJECTIVES: To characterize and compare ambulatory antibiotic prescribing for children in US pediatric and nonpediatric emergency departments (EDs). METHODS: A cross-sectional retrospective study of patients aged 0 to 17 years discharged from EDs in the United States was conducted by using the 2009–2014 National Hospital Ambulatory Medical Care Survey ED data. We estimated the proportion of ED visits resulting in antibiotic prescriptions, stratified by antibiotic spectrum, class, diagnosis, and ED type ("pediatric" defined as >75% of visits by patients aged 0–17 years, versus "nonpediatric"). Multivariable logistic regression was used to determine factors independently associated with first-line, guideline-concordant prescribing for acute otitis media, pharyngitis, and sinusitis. RESULTS: In 2009–2014, of the 29 million mean annual ED visits by children, 14% (95% confidence interval [CI]: 10%–20%) occurred at pediatric EDs. Antibiotics overall wer...

Roseola infantum is an infection caused by a type of herpes virus. It typically affects babies and toddlers. Other names for this health issue are sixth disease, exanthema subitum, or just "roseola." Around 90% of roseola cases occur before 2 years of age. Roseola results from infection with one of two main strains of the human herpesvirus (HHV): HHV-6 or HHV-7. Below, we describe how to identify roseola and how to tell the difference between it and measles. We also look into whether treatment is necessary. Roseola has a distinctive progression : A high fever develops, possibly suddenly, and may last for 3–5 days. A distinctive rash appears, usually on the torso, as the fever ends. The rash may spread to the neck, face, and limbs within 24 hours. The rash disappears after 1–2 days. Roseola usually affects toddlers and babies under 2 years old . They may also have or show: general discomfort irritability an unwillingness to eat diarrhea a cough swelling or redness around the ...

Iron deficiency anemia (IDA) occurs when the body lacks the right amount of iron to produce enough healthy red blood cells to carry oxygen to the body's tissues. While there are different types of anemia, IDA is the most common worldwide, affecting over 1.2 billion people. People with IDA that is mild or moderate may not experience symptoms. More severe cases of iron deficiency will cause chronic fatigue, shortness of breath, or chest pain. IDA needs to be addressed and treated. Left untreated, it can lead to depression, heart problems, increased infection risk, developmental delays in children, and pregnancy complications. Keep reading to learn about the symptoms and complications of IDA and when to see a doctor. AsiaVision / E+ / Getty Images Common Symptoms Signs and symptoms of IDA depend on a variety of factors, including severity, how fast the condition develops, your age, and your health. Some people with iron deficienc...

July 09, 2021 6 min read ADD TOPIC TO EMAIL ALERTS Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . " data-action="subscribe"> Subscribe ADDED TO EMAIL ALERTS We were unable to process your request. Please try again later. If you continue to have this issue please contact customerservice@slackinc.com. Back to Healio A 19-year-old man presented to the New England Eye Center's retina service with new distortion and a scotoma in the lef...

Abstract Chronic suppurative otitis media (CSOM) is a neglected pediatric disease affecting 330 million worldwide for which no new drugs have been introduced for over a decade. We developed a mouse model with utility in preclinical drug evaluation and antimicrobial discovery. Our model used immune-competent mice, tympanic membrane perforation and inoculation with luminescent Pseudomonas aeruginosa that enabled bacterial abundance tracking in real-time for 100 days. The resulting chronic infection exhibited hallmark features of clinical CSOM, including inhibition of tympanic membrane healing and purulent ear discharge. We evaluated the standard care fluoroquinolone ofloxacin and demonstrated that this therapy resulted in a temporary reduction of bacterial burden. These data are consistent with the clinical problem of persistent infection in CSOM and the need for therapeutic outcome measures that assess eradication post-therapeutic endpoint. We conclude that this novel mouse model of CSO...